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Four animals, who were experimented on by the evil Dr. Polar and given the ability to transform into humans during the day, escape their captor, and decide to start the Reese-Renee Veterinary Practice, where they work to help other animals in need. Not only is the vet practice something they are all passionate about, but it also gives them a good place to take cover from Dr. Polar, who has her teams scouring all over the United States to find them.

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